Agglomeration of Spray-Dried Milk Powder in a Spray Fluidized Bed: A Morphological Modeling

Milk powder agglomerate growth and properties in fluidized bed agglomeration

Fluidized bed agglomeration is used to produce large and porous dry agglomerates with improved instant properties. Water (or binder solution) is sprayed in the fluidized bed of particles to render their surface sticky. The agglomerate growth results from the repetition of different steps (wetting of the particle surface, particles collision and bridging, and drying) and depends on the processin...

Experimental Study of Fluidized Bed Agglomeration of Acerola Powder

The aim of this work was to study the main effects of acerola powder on fluidized bed agglomeration. A 2 fractional factoring design was used to evaluate the main operating conditions (fluidizing air temperature, fluidizing air velocity, atomizing air flow and height of nozzle in the bed). The mechanical and physicochemical product changes were determined by analysis of particle diameter, moist...

Effect of Process Variables on Growth Kinetics of Lactose Particles in a Wet Spray Fluidized Bed Granulator

Fluidized Bed Spray Granulation – From process understanding to modeling of nucleation and dust integration

Fluidized bed spray granulation is a process to obtain coarse-grained particles directly from suspensions, solutions or melts, ready for sale without any need for post-treatment. The process combines spray drying with granulation and classification, thus allowing the product particle size distribution to be adjusted according to customer demands. Well-known applications include pharmaceutical p...

Spray-Dried Lactose

pray-dried (SD) lactose was introduced to the pharmaceutical market in the 1960s as an excipient that enables direct compression of formulations in a simple manufacturing process (1). To this day, lactose remains one of the most popular excipients for active pharmaceutical ingredients (APIs) whose dose makes them suitable for direct compression. Several manufacturers make and sell SD lactose, a...